Dnmt1^tm4.1Jrc
Targeted Allele Detail

Summary

• Symbol: Dnmt1^tm4.1Jrc
• Name: DNA methyltransferase 1; targeted mutation 4.1, Richard Chaillet
• MGI ID: MGI:5752869
• Synonyms: Dnmt1^IDel13
• Gene: Dnmt1 Location: Chr9:20818501-20871084 bp, - strand Genetic Position: Chr9, 7.66 cM
• Alliance: Dnmt1^tm4.1Jrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223970
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: A nucleotide was inserted in the 5' end of exon 13 and an exon was deleted from the 3' end of exon 13, altering the amino acids across the exon encoding the conserved and mouse rat differential regions of the intrisically disordered domain (IDD). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of exon 12. (J:223970)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnmt1 Mutation: 110 strains or lines available

References

• Original: J:223970 Shaffer B, et al., The DNMT1 intrinsically disordered domain regulates genomic methylation during development. Genetics. 2015 Feb;199(2):533-41
• All: 1 reference(s)