Sema3b^tm2.1Cast
Targeted Allele Detail

Summary

• Symbol: Sema3b^tm2.1Cast
• Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; targeted mutation 2.1, Valerie Castellani
• MGI ID: MGI:5755126
• Synonyms: Sema3B-GFP
• Gene: Sema3b Location: Chr9:107474873-107486428 bp, - strand Genetic Position: Chr9, 58.31 cM
• Alliance: Sema3b^tm2.1Cast page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221787
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: An EGFP sequence was inserted in exon 4 creating a fusion with the N terminal part of the gene, a loxP site was inserted upstream of exon 3, and a loxP site and FRT flanked selection cassette were inserted downstream of exon 6 via homologous recombination. Flp mediated recombination removed the selection cassette. (J:221787)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sema3b Mutation: 31 strains or lines available

References

• Original: J:221787 Arbeille E, et al., Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis. Nat Commun. 2015;6:6366
• All: 1 reference(s)