Ido1^tm1.1Mkks
Targeted Allele Detail

Summary

• Symbol: Ido1^tm1.1Mkks
• Name: indoleamine 2,3-dioxygenase 1; targeted mutation 1.1, Mark K Santillan
• MGI ID: MGI:5775113
• Gene: Ido1 Location: Chr8:25074148-25086987 bp, - strand Genetic Position: Chr8, 12.76 cM
• Alliance: Ido1^tm1.1Mkks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229059
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced exons 2 through 10. Cre-mediate recombination removed the selection cassette. RT-PCR confirmed transcript expression below detectable limits in the spleen, heart, kidney, liver and lung. (J:229059)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ido1 Mutation: 29 strains or lines available

References

• Original: J:229059 Santillan MK, et al., Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. Physiol Rep. 2015 Jan 1;3(1)
• All: 2 reference(s)