Pik3catm1.1Rps
Targeted Allele Detail
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Symbol: |
Pik3catm1.1Rps |
Name: |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1.1, Ramon Parsons |
MGI ID: |
MGI:5776387 |
Gene: |
Pik3ca Location: Chr3:32451203-32520256 bp, + strand Genetic Position: Chr3, 15.7 cM, cytoband B
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Alliance: |
Pik3catm1.1Rps page
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Germline Transmission: |
Earliest citation of germline transmission:
J:222915
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Not Specified) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: Exon 9 was replaced with a floxed splice acceptor/neomycin resistance cassette and a modified exon 9 in which a G to A mutation results in the amino acid substitution of lysine for glutamic acid at position 545 (E545K). Cre-mediated recombination removed the selection cassette.
(J:222915)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pik3ca Mutation: |
63 strains or lines available
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Original: |
J:222915 Stratikopoulos EE, et al., Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy. Cancer Cell. 2015 Jun 8;27(6):837-51 |
All: |
1 reference(s) |
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