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Ightm3.1(VRC01)Nemz
Targeted Allele Detail
Summary
Symbol: Ightm3.1(VRC01)Nemz
Name: immunoglobulin heavy chain complex; targeted mutation 3.1, David Nemazee
MGI ID: MGI:5779356
Synonyms: VRC01 gH
Gene: Igh  Location: Chr12:113222388-115973574 bp, - strand  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:225518
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette replaced the DQ52-JH cluster in the Igh locus with the HIV broadly neutralizing antibody precursor VRC01 gH VDJ exon. The upstream promoter, leader and intron elements were from VHJ558.85.191. Cre-mediated recombination removed the neomycin resistance cassette. (J:225518)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  44 strains or lines available
References
Original:  J:225518 Jardine JG, et al., HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen. Science. 2015 Jul 10;349(6244):156-61
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory