Tg(Foxp3-HBEGF/EGFP)1Doi
Transgene Detail

Summary

• Symbol: Tg(Foxp3-HBEGF/EGFP)1Doi
• Name: transgene insertion 1, Christophe Benoist
• MGI ID: MGI:5789576
• Synonyms: Foxp3-DTR, Foxp3^DTR
• Transgene: Tg(Foxp3-HBEGF/EGFP)1Doi Location: unknown
• Alliance: Tg(Foxp3-HBEGF/EGFP)1Doi page

Transgene origin

• Strain of Origin: NOD/ShiLtJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Foxp3-HBEGF/EGFP)1Doi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

  fused to EGFP

• Mutation details: A BAC containing Foxp3 was modified by inserting a human heparin-binding EGF-like growth factor (HBEGF or DTR, diptheria toxin receptor) sequence fused to an enhanced green fluorescent protein (EGFP) with a stop codon between the first and second codons of the Foxp3 open reading frame. (J:153752)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:153752 Feuerer M, et al., How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity. 2009 Oct 16;31(4):654-64
• All: 7 reference(s)