Lrba^tm1.1Kili
Targeted Allele Detail

Summary

• Symbol: Lrba^tm1.1Kili
• Name: LPS-responsive beige-like anchor; targeted mutation 1.1, Manfred W Kilimann
• MGI ID: MGI:5796558
• Synonyms: Lrba2-A-C9
• Gene: Lrba Location: Chr3:86131987-86689999 bp, + strand Genetic Position: Chr3, 37.83 cM, cytoband F1
• Alliance: Lrba^tm1.1Kili page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249357
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The third coding exon (also known as exon 4) was removed. Recombination removed the selection cassette. Deletion of exon 3 generates a frameshift after 5% of the coding sequence (149 aa) giving rise to a constitutive knock-out. Immunoblot analysis shows that protein is undetectable in brain and kidney. (J:249357)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrba Mutation: 139 strains or lines available

References

• Original: J:249357 Kurtenbach S, et al., The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia. Sci Rep. 2017 Aug 16;7(1):8409
• All: 4 reference(s)