Tex15em1Jcs
Endonuclease-mediated Allele Detail
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Symbol: |
Tex15em1Jcs |
Name: |
testis expressed gene 15 meiosis and synapsis associated; endonuclease-mediated mutation 1, John C Schimenti |
MGI ID: |
MGI:5804172 |
Synonyms: |
Tex15T2181I |
Gene: |
Tex15 Location: Chr8:34006766-34075610 bp, + strand Genetic Position: Chr8, 20.59 cM
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Alliance: |
Tex15em1Jcs page
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Allele Type: |
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Endonuclease-mediated (Humanized sequence) |
Mutation: |
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Nucleotide substitutions
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Mutation details: Using an sgRNA (targeting AGTTTCCACGTATATTGACT) and ssODN template (AACTTACAGGCGTTAAAAGGCTTCTGAATAACTCTAAGTATTCAGTTTCCATATATATTGACTTGGTGCCACATACTGCATCTGTAAATTTTGGAAACACTGTGGCAGAATTAGAACATAACTACA) with CRISPR/Cas9 technology, threonine codon 2188 (ACG) was changed to isoleucine (ATA) (c.6563_6564delCGinsTA, p.T2188I). This is the equivalent of the human p.T2181I mutation caused by SNP rs61735519.
(J:226562)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tex15 Mutation: |
114 strains or lines available
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Original: |
J:226562 Singh P, et al., The genetics of human infertility by functional interrogation of SNPs in mice. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10431-6 |
All: |
1 reference(s) |
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