Malt1^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Malt1^tm1.2Geno
• Name: MALT1 paracaspase; targeted mutation 1.2, Genoway
• MGI ID: MGI:5805284
• Gene: Malt1 Location: Chr18:65564010-65611959 bp, + strand Genetic Position: Chr18, 38.56 cM
• Alliance: Malt1^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235331
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of a modified exon 12. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the modified exon 12. Western blot analysis confirmed the absence of protein expression in the spleen. (J:235331)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Malt1 Mutation: 33 strains or lines available

References

• Original: J:235331 Yu JW, et al., MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses. PLoS One. 2015;10(5):e0127083
• All: 1 reference(s)