Gt(ROSA)26Sor^{tm1(Ptbp1)Szhg}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Ptbp1)Szhg}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Sika Zheng
• MGI ID: MGI:5805526
• Synonyms: Rosa26^LSL-FL-Ptbp1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Ptbp1)Szhg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239441
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Ptbp1)Szhg} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ptbp1 (MGI:97791)

• Mutation details: A targeting vector was designed with a splice acceptor site followed by a loxP-flanked neomycin resistance cassette fused to a polyadenylation signal. This was followed by (from 5' to 3') an FRT site, a FLAG-tagged mouse cDNA, and an internal ribosome entry site (IRES) fused to a nuclear localization signal and an mCherry sequence, and a second FRT site. (J:239441)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 958 strains or lines available

References

• Original: J:239441 Vuong JK, et al., PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing. Cell Rep. 2016 Dec 06;17(10):2766-2775
• All: 1 reference(s)