Inpp5e^tm1.1Cmit
Targeted Allele Detail

Summary

• Symbol: Inpp5e^tm1.1Cmit
• Name: inositol polyphosphate-5-phosphatase E; targeted mutation 1.1, Christina A Mitchell
• MGI ID: MGI:5823280
• Synonyms: Inpp5e^-
• Gene: Inpp5e Location: Chr2:26286261-26299215 bp, - strand Genetic Position: Chr2, 18.88 cM, cytoband A3
• Alliance: Inpp5e^tm1.1Cmit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236703
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites were inserted to flank exons 2-6. Cre-mediated recombination resulted in the deletion of the flanked exons. (J:236703)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inpp5e Mutation: 29 strains or lines available

References

• Original: J:236703 Hakim S, et al., Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling. Hum Mol Genet. 2016 Jun 1;25(11):2295-2313
• All: 2 reference(s)