Tlr9^tm1.1Spar
Targeted Allele Detail

Summary

• Symbol: Tlr9^tm1.1Spar
• Name: toll-like receptor 9; targeted mutation 1.1. Tim Sparwasser
• MGI ID: MGI:5897276
• Synonyms: TLR9^fl
• Gene: Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Tlr9^tm1.1Spar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240754
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and an FRT site flanked neomycin resistance gene cassette were inserted into intron 1. An F3 site flanked puromycin resistance gene cassette and a second loxP site were inserted into intron 2. The neo and puro cassettes were removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with a floxed exon 2. (J:240754)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr9 Mutation: 65 strains or lines available

References

• Original: J:240754 Puttur F, et al., Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling. Cell Rep. 2016 Oct 18;17(4):1113-1127
• All: 1 reference(s)