Prnp^tm1.1Jcmn
Targeted Allele Detail

Summary

• Symbol: Prnp^tm1.1Jcmn
• Name: prion protein; targeted mutation 1.1, Jean C Manson
• MGI ID: MGI:5902578
• Synonyms: HuM
• Gene: Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
• Alliance: Prnp^tm1.1Jcmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241425
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with the corresponding human sequence containing the methionine at position 129 polymorphism. Cre-mediated recombination removed a floxed neomycin resistance cassette inserted into downstream of exon 3. (J:241425)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prnp Mutation: 149 strains or lines available

References

• Original: J:241425 Bishop MT, et al., Predicting susceptibility and incubation time of human-to-human transmission of vCJD. Lancet Neurol. 2006 May;5(5):393-8
• All: 1 reference(s)