Ptpn2^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Ptpn2^{tm1c(EUCOMM)Wtsi}
• Name: protein tyrosine phosphatase, non-receptor type 2; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5902694
• Synonyms: Ptpn2^fl
• Gene: Ptpn2 Location: Chr18:67798581-67857665 bp, - strand Genetic Position: Chr18, 40.06 cM
• Alliance: Ptpn2^{tm1c(EUCOMM)Wtsi} page
• IMPC: Ptpn2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241363
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 67828466 of Chromosome 18 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 67829274. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. (J:241363)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn2 Mutation: 43 strains or lines available

References

• Original: J:241363 Lee H, et al., Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development. Sci Rep. 2017 Mar 21;7:45077
• All: 9 reference(s)