Col15a1^tm1.1Jjco
Targeted Allele Detail

Summary

• Symbol: Col15a1^tm1.1Jjco
• Name: collagen, type XV, alpha 1; targeted mutation 1.1, Jessica Connelly
• MGI ID: MGI:5906024
• Synonyms: Col15a1^fl
• Gene: Col15a1 Location: Chr4:47208161-47313167 bp, + strand Genetic Position: Chr4, 26.01 cM, cytoband B1-B3
• Alliance: Col15a1^tm1.1Jjco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241641
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector contains a loxP site upstream of exon 1 and a FRT-site flanked PGK-neo-bGHpA cassette followed by a loxP downstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 1 and 2 floxed. (J:241641)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Col15a1 Mutation: 71 strains or lines available

References

• Original: J:241641 Durgin BG, et al., Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions. Am J Physiol Heart Circ Physiol. 2017 May 01;312(5):H943-H958
• All: 1 reference(s)