Mgll^tm1.2Rzim
Targeted Allele Detail

Summary

• Symbol: Mgll^tm1.2Rzim
• Name: monoglyceride lipase; targeted mutation 1.2, Robert Zimmermann
• MGI ID: MGI:5911442
• Gene: Mgll Location: Chr6:88701397-88805342 bp, + strand Genetic Position: Chr6, 39.51 cM
• Alliance: Mgll^tm1.2Rzim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228956
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the neo cassette leaving exons 3 and 4 floxed. (J:172679, J:228956)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mgll Mutation: 29 strains or lines available

References

• Original: J:228956 Grabner GF, et al., Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation. J Biol Chem. 2016 Jan 8;291(2):913-23
• All: 2 reference(s)