Tg(Pax8-cre/ERT2)CAmat
Transgene Detail

Summary

• Symbol: Tg(Pax8-cre/ERT2)CAmat
• Name: transgene insertion C, Athena Matakidou
• MGI ID: MGI:5911838
• Synonyms: Pax8-CreER^T2
• Transgene: Tg(Pax8-cre/ERT2)CAmat Location: unknown Genetic Position: Chr6, cytoband 6qC1
• Alliance: Tg(Pax8-cre/ERT2)CAmat page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Pax8-cre/ERT2)CAmat expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pax8 (MGI:97492)

• Mutation details: A DNA fragment encoding the cre/ERT2 fusion protein with a poly A sequence was inserted at the endogenous ATG translational start site of a murine Pax8 sequence. The construct was injected into C57BL/6J blastocysts. Five transgenic founders were identified, and data for one of them (Line C) is reported. The transgene integration in this line was localized via fluorescence in situ hybridization and paired-end whole genome sequencing to an intergenic region of Chr 6qC1 (chr6:62,912,590-62,912,610; GRCh38/mm10). (J:243751)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax8 (mouse) Summary of all recombinase alleles driven by Pax8. Alliance mouse Pax8 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:243751 Espana-Agusti J, et al., Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells. PLoS One. 2016;11(2):e0148055
• All: 3 reference(s)