Postn^tm1Johu
Targeted Allele Detail

Summary

• Symbol: Postn^tm1Johu
• Name: periostin, osteoblast specific factor; targeted mutation 1, Joerg Huelsken
• MGI ID: MGI:5925215
• Gene: Postn Location: Chr3:54268530-54298458 bp, + strand Genetic Position: Chr3, 25.46 cM
• Alliance: Postn^tm1Johu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245942
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A STOP cassette was inserted into exon 1. Exon 1 contains the secretion signal, so any products from putative downstream alternative transcription and translation start sites would be non-functional. (J:245942)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Postn Mutation: 52 strains or lines available

References

• Original: J:245942 Malanchi I, et al., Interactions between cancer stem cells and their niche govern metastatic colonization. Nature. 2011 Dec 07;481(7379):85-9
• All: 3 reference(s)