Tg(TLR4*D299G)4Haj
Transgene Detail

Summary

• Symbol: Tg(TLR4*D299G)4Haj
• Name: transgene insertion 4, Adeline M Hajjar
• MGI ID: MGI:6094862
• Transgene: Tg(TLR4*D299G)4Haj Location: unknown
• Alliance: Tg(TLR4*D299G)4Haj page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TLR4*D299G)4Haj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TLR4 (7099)

  Tlr4	(MGI:96824)

  Mutated human gene resulting in Asp299Gly substitution

• Mutation details: The transgene was generated with a modified version of human genomic BAC RP11-150L1. Using recombineering, an A>G substitution was introduced that resulted in a D299G (p.Asp299Gly) mutation in the translated petide. The copy number of this allele, as determined by RT-PCR, is 4. (J:248428)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:248428 Hajjar AM, et al., Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness. PLoS One. 2017;12(10):e0186308
• All: 1 reference(s)