Glis3^tm2Amj
Targeted Allele Detail

Summary

• Symbol: Glis3^tm2Amj
• Name: GLIS family zinc finger 3; targeted mutation 2, Anton M Jetten
• MGI ID: MGI:6099094
• Synonyms: Glis3^GFP, Glis3^{tm3(Glis3-EGFP)Amj}
• Gene: Glis3 Location: Chr19:28236251-28657477 bp, - strand Genetic Position: Chr19, 22.88 cM
• Alliance: Glis3^tm2Amj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249276
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An EGFP coding region was inserted into exon 10 of the gene, right before the TGA stop codon. A Glis3-EGFP fusion protein is expressed. An frt-flanked neomycin selection cassette was also inserted between exons 10 and 11. (J:249276)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glis3 Mutation: 40 strains or lines available

References

• Original: J:249276 Kang HS, et al., The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells. PLoS One. 2016;11(6):e0157138
• All: 5 reference(s)