Gt(ROSA)26Sortm1(tetO-Yap1*,-GFP*)Stang
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(tetO-Yap1*,-GFP*)Stang |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ben Stanger |
MGI ID: |
MGI:6115248 |
Synonyms: |
tetO-YAP-GFP |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(tetO-Yap1*,-GFP*)Stang page
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Allele Type: |
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Targeted (Inducible, Inserted expressed sequence, Reporter) |
Inducer: |
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doxycycline/tetracycline |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: The targeting vector contains a loxP site flanked PGK-neo cassette, a mutant mouse Yap1 gene (with an amino acid substitution of serine-to-alanine at position 112), viral 2A peptide sequence, HIST1H2BJ/GFP (H2B-GFP) cDNA, beta-globin and polyadenylation sequence, under the control of the tetO, tetracycline-responsive regulatory element (TRE-tight).
(J:255620)
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Original: |
J:255620 Gao T, et al., Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology. 2013 Jun;144(7):1543-53, 1553.e1 |
All: |
5 reference(s) |
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