Iho1tm1Atot
Targeted Allele Detail
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Symbol: |
Iho1tm1Atot |
Name: |
interactor of HORMAD1 1; targeted mutation 1, Attila Toth |
MGI ID: |
MGI:6116833 |
Synonyms: |
Iho1insertion |
Gene: |
Iho1 Location: Chr9:108280810-108305683 bp, - strand Genetic Position: Chr9, 59.32 cM
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Alliance: |
Iho1tm1Atot page
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Allele Type: |
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Targeted (Conditional ready, Null/knockout, Reporter) |
Mutation: |
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Insertion
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Mutation details: Clone HTGRS6006_A_G10 from the BACPAC Resources Center, Knockout Mouse Project KOMP repository was used to target embryonic stem cells. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. The first loxP site is followed by a neomycin under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 3. Exon 3 is thus flanked by loxP sites. Western blot analysis confirmed absence of the full-length protein in testis.
(J:238496)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Iho1 Mutation: |
25 strains or lines available
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Original: |
J:238496 Stanzione M, et al., Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice. Nat Cell Biol. 2016 Nov;18(11):1208-1220 |
All: |
1 reference(s) |
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