P2rx4^tm1.1Btlg
Targeted Allele Detail

Summary

• Symbol: P2rx4^tm1.1Btlg
• Name: purinergic receptor P2X, ligand-gated ion channel 4; targeted mutation 1.1 Bruce T Liang
• MGI ID: MGI:6117070
• Synonyms: P2rx4^tm1.1Ngc, P2X4^floxed
• Gene: P2rx4 Location: Chr5:122845607-122867801 bp, + strand Genetic Position: Chr5, 62.53 cM
• Alliance: P2rx4^tm1.1Btlg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256850
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 4 and the second loxP site together with the Frt-PGKneo-Frt cassette was inserted in intron 1. The PGKneo cassette was removed by FLP-mediated recombination. (J:256850)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2rx4 Mutation: 26 strains or lines available

References

• Original: J:256850 Yang T, et al., Novel protective role of endogenous cardiac myocyte P2X4 receptors in heart failure. Circ Heart Fail. 2014 May;7(3):510-8
• All: 6 reference(s)