Tox3^{tm1c(KOMP)Mbp}
Targeted Allele Detail

Summary

• Symbol: Tox3^{tm1c(KOMP)Mbp}
• Name: TOX high mobility group box family member 3; targeted mutation 1c, Mouse Biology Program, UC Davis
• MGI ID: MGI:6119412
• Gene: Tox3 Location: Chr8:90973668-91074971 bp, - strand Genetic Position: Chr8, 43.96 cM
• Alliance: Tox3^{tm1c(KOMP)Mbp} page
• IMPC: Tox3 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 90979090 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 90981633. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:157064)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tox3 Mutation: 38 strains or lines available

References

• Original: J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010
• All: 3 reference(s)