Grpr^tm1.1Zfc
Targeted Allele Detail

Summary

• Symbol: Grpr^tm1.1Zfc
• Name: gastrin releasing peptide receptor; targeted mutation 1.1, Zhou-Feng Chen
• MGI ID: MGI:6121102
• Synonyms: Grpr^F
• Gene: Grpr Location: ChrX:162296900-162332673 bp, - strand Genetic Position: ChrX, 75.63 cM
• Alliance: Grpr^tm1.1Zfc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240537
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted approximately 0.5 kb upstream of exon 2 and an FRT-flanked neomycin resistance gene and a loxP site were inserted about 0.8 kb downstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 2 floxed. (J:240537)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grpr Mutation: 14 strains or lines available

References

• Original: J:240537 Yu YQ, et al., Molecular and neural basis of contagious itch behavior in mice. Science. 2017 Mar 10;355(6329):1072-1076
• All: 1 reference(s)