Rps6kb1^tm1.1Pgho
Targeted Allele Detail

Summary

• Symbol: Rps6kb1^tm1.1Pgho
• Name: ribosomal protein S6 kinase, polypeptide 1; targeted mutation 1.1, Paritosh Ghosh
• MGI ID: MGI:6147685
• Synonyms: p70^S6K1 KO
• Gene: Rps6kb1 Location: Chr11:86389697-86435631 bp, - strand Genetic Position: Chr11, 51.82 cM
• Alliance: Rps6kb1^tm1.1Pgho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234010
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8-12 were replaced with a neo cassette flanked by loxP sites. Cre-mediated recombination removed the neo cassette. (J:234010)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rps6kb1 Mutation: 55 strains or lines available

References

• Original: J:234010 Sasaki CY, et al., p((7)(0)S(6)K(1)) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice. Eur J Immunol. 2016 Jan;46(1):212-22
• All: 1 reference(s)