Gli2^{tm3(Gli2/EGFP)Reit}
Targeted Allele Detail

Summary

• Symbol: Gli2^{tm3(Gli2/EGFP)Reit}
• Name: GLI-Kruppel family member GLI2; targeted mutation 3, Jeremy Reiter
• MGI ID: MGI:6147792
• Synonyms: Gli2^{Gt(XG045)Byg.tm3(Gli2FlagEgfp)Reit}
• Gene: Gli2 Location: Chr1:118761862-118981349 bp, - strand Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
• Alliance: Gli2^{tm3(Gli2/EGFP)Reit} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258389
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Epitope tag, Reporter)
• Mutation: Insertion
• Mutation details: In ES cells carrying Gli2 ^Gt(XG045)Byg the gene trap locus was modified between a lox71 site and a lox66 site to insert a Gl12 cDNA fused to GFP and a FLAG tag. (J:258389)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gli2 Mutation: 169 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:258389 Raleigh DR, et al., Hedgehog signaling drives medulloblastoma growth via CDK6. J Clin Invest. 2018 Jan 2;128(1):120-124
• All: 1 reference(s)