Alpl^tm3.1Jlm
Targeted Allele Detail

Summary

• Symbol: Alpl^tm3.1Jlm
• Name: alkaline phosphatase, liver/bone/kidney; targeted mutation 3.1, Jose Luis Millan
• MGI ID: MGI:6147857
• Synonyms: Alpl^fl
• Gene: Alpl Location: Chr4:137469044-137523695 bp, - strand Genetic Position: Chr4, 70.02 cM
• Alliance: Alpl^tm3.1Jlm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257909
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 3-4 were flanked by loxP sites. The FRT-flanked neomycin cassette that was inserted was removed via flp-mediated recombination.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alpl Mutation: 351 strains or lines available

References

• Original: J:257909 Foster BL, et al., Conditional Alpl Ablation Phenocopies Dental Defects of Hypophosphatasia. J Dent Res. 2017 Jan;96(1):81-91
• All: 2 reference(s)