Tg(RHD)1Goo
Transgene Detail
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Symbol: |
Tg(RHD)1Goo |
Name: |
transgene insertion 1, Dominique Goossens |
MGI ID: |
MGI:6148219 |
Synonyms: |
RHD-BAC1, TG_RHD_BAC1 |
Transgene: |
Tg(RHD)1Goo Location: unknown
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Alliance: |
Tg(RHD)1Goo page
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Strain of Origin: |
C57BL/6 x SJL
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(RHD)1Goo expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
RHD (6007) |
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Mutation details: A human BAC (BAC H0193H09 from the CEPH) carrying RHD gene was used to make transgenic mice. Transcripts from the human gene are detected, but no protein expression was detected with a panel of anti-RhD monoclonal antibodies recognizing different epitopes or a polyclonal anti-RhD. Human RhD protein is not expressed in mouse erythroid cells in the absence of human RHAG despite the presence of murine Rhag. In the presence of human RHAG, a low level of human RHD is detectable.
(J:209676)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:209676 Goossens D, et al., Mice expressing RHAG and RHD human blood group genes. PLoS One. 2013;8(11):e80460 |
All: |
1 reference(s) |
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