Hprt1^{tm3(Zfy2*)Jtu}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm3(Zfy2*)Jtu}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 3, James Turner
• MGI ID: MGI:6149948
• Synonyms: Zfy2(nf)
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm3(Zfy2*)Jtu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172406
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Hprt1^{tm3(Zfy2*)Jtu} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Zfy2 (MGI:99213)

• Mutation details: The mouse BAC (CITB-5288D7) was used to make targeted transgenic mice, but an unexpected deletion in the BAC resulted in the deletion of the Zfy2 gene. X-chromosome directed transgenesis was performed by cassette mediated exchange (CME). This line is used as a control for other targeted transgenic lines with insertions into the HPRT locus. (J:172406)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1277 strains or lines available

References

• Original: J:172406 Vernet N, et al., The y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice. Curr Biol. 2011 May 10;21(9):787-93
• All: 2 reference(s)