Tg(Dmp1-PTH1R*H223R)564Btm
Transgene Detail

Summary

• Symbol: Tg(Dmp1-PTH1R*H223R)564Btm
• Name: transgene insertion 564, Teresita Bellido
• MGI ID: MGI:6151434
• Synonyms: DMP1-caPTHR1
• Transgene: Tg(Dmp1-PTH1R*H223R)564Btm Location: unknown
• Alliance: Tg(Dmp1-PTH1R*H223R)564Btm page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Dmp1-PTH1R*H223R)564Btm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTH1R (5745)

  Pth1r

  (MGI:97801)

  includes a H223R mutation

• Mutation details: The transgenic construct contains a mouse Dmp1 promoter, including 8kb of the 5' flanking region, the first exon, the first intron, and 17 bp of exon 2, followed by a modified human PTHR1 gene, and a rabbit beta-globin polyA sequence. PTHR1 contains a histidine to arginine substitution at residue 223 (H223R or c.668A>G); the substitution results in constitutively active expression of PTHR1. (J:140592)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:140592 O'Brien CA, et al., Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS One. 2008;3(8):e2942
• All: 8 reference(s)