Qki^tm1Jnhu
Targeted Allele Detail

Summary

• Symbol: Qki^tm1Jnhu
• Name: quaking, KH domain containing RNA binding; targeted mutation 1, Jian Hu
• MGI ID: MGI:6155623
• Synonyms: Qk^L, Qk-loxP
• Gene: Qki Location: Chr17:10425480-10538706 bp, - strand Genetic Position: Chr17, 7.75 cM
• Alliance: Qki^tm1Jnhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260936
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. (J:260936)

Tumor Data

List all tumor models in MMHCdb carrying Qki^tm1Jnhu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Qki Mutation: 26 strains or lines available

References

• Original: J:260936 Shingu T, et al., Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nat Genet. 2017 Jan;49(1):75-86
• All: 5 reference(s)