H2-Ab1^g7-em1Mvw
Endonuclease-mediated Allele Detail

Summary

• Symbol: H2-Ab1^g7-em1Mvw
• Name: histocompatibility 2, class II antigen A, beta 1; endonuclease-mediated mutation 1, Michael Wiles
• MGI ID: MGI:6156109
• Synonyms: H2-Ab1^em1Mvw, IA^null
• Gene: H2-Ab1 Location: Chr17:34482201-34488392 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-Ab1^g7-em1Mvw page

Mutation origin

• Strain of Origin: NOD.Cg-Prkdc^scid H2-K1^b-tm1Bpe H2-D1^b-tm1Bpe Il2rg^tm1Wjl/Sz

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This TALEN-mediated null mutation has a 61 bp deletion in exon 2, Chr 17: :34264928-34264988 (GRCm38), followed by 39 bp of retained endogenous sequence, then a 507 bp deletion, Chr 17: 34265028-34265534, with a 7 bp insertion (CCGTCAC) in its place, the impact of which is a disruption of most of exon 2. Flow cytometric analysis confirmed this to be a null allele. (J:268035)
• Inheritance: Not Specified

Tumor Data

List all tumor models in MMHCdb carrying H2-Ab1^g7-em1Mvw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any H2-Ab1 Mutation: 83 strains or lines available

References

• Original: J:268035 Brehm MA, et al., Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression. FASEB J. 2018 Nov 1;:fj201800636R
• All: 5 reference(s)