Mdm4tm1.1Chj
Targeted Allele Detail
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Symbol: |
Mdm4tm1.1Chj |
Name: |
transformed mouse 3T3 cell double minute 4; targeted mutation 1.1, Jiandong Chen |
MGI ID: |
MGI:6156967 |
Synonyms: |
MDMXSG |
Gene: |
Mdm4 Location: Chr1:132913843-132958325 bp, - strand Genetic Position: Chr1, 57.75 cM, cytoband G-G
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Alliance: |
Mdm4tm1.1Chj page
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Germline Transmission: |
Earliest citation of germline transmission:
J:261424
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S6/SvEvTac and C57BL/6
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Allele Type: |
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Targeted (Hypomorph) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: A floxed neo cassette was inserted in intron 7 and W201S/W202G mutations were inserted in exon 8 via homologous recombination. Cre mediated recombination removed the neo cassette. This mutation disrupts intramolecular interactions and binding to CSNK1A1 and acidic domain-TRP53 core binding.
(J:261424)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mdm4 Mutation: |
191 strains or lines available
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Original: |
J:261424 Huang Q, et al., MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3368-E3377 |
All: |
2 reference(s) |
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