Cd5^a
Spontaneous Allele Detail

Summary

• Symbol: Cd5^a
• Name: CD5 antigen; a variant
• MGI ID: MGI:6157436
• Synonyms: CD5.1, Ly-1.1
• Gene: Cd5 Location: Chr19:10695471-10716390 bp, - strand Genetic Position: Chr19, 7.16 cM
• Alliance: Cd5^a page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Spontaneous (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Sequence analysis of C3H/HeJ showed that this polymorphic variant has point mutations relative to the b variant that result in valine instead of isoleucine at amino acid 9, leucine instead of glutamine at amino acid 52, and isoleucine instead of phenylalanine at amino acid 71, all within the amino terminal scavenger receptor cysteine-rich D1 domain, in addition to 7 silent point mutations. This allele is found in many inbred strains including CBA/J, C3H and DBA substrains. (J:8546, J:40410)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Cd5 Mutation: 36 strains or lines available

References

• Original: J:5073 Boyse EA, et al., Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(19):175-93
• All: 10 reference(s)