Mybpc3tm1d(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Mybpc3tm1d(EUCOMM)Hmgu |
Name: |
myosin binding protein C, cardiac; targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:6160322 |
Synonyms: |
Mybpc3- |
Gene: |
Mybpc3 Location: Chr2:90948489-90966861 bp, + strand Genetic Position: Chr2, 50.44 cM, cytoband E1
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Alliance: |
Mybpc3tm1d(EUCOMM)Hmgu page
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IMPC: |
Mybpc3 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:262067
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 91119563 of Chromosome 2 into intron 2 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted into intron 5 at position 91120795. Exons 3-5 are thus flanked by loxP sites. The lacZ and neo cassettes were removed through subsequent flp-mediated recombination and exons 3-5 were deleted through cre-mediated recombination.
(J:262067)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mybpc3 Mutation: |
41 strains or lines available
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Original: |
J:262067 Matsuyama S, et al., Interaction between cardiac myosin-binding protein C and formin Fhod3. Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4386-E4395 |
All: |
5 reference(s) |
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