Arrb2^tm1Stam
Targeted Allele Detail

Summary

• Symbol: Arrb2^tm1Stam
• Name: arrestin, beta 2; targeted mutation 1, Jonathan S Stamler
• MGI ID: MGI:6164024
• Synonyms: Betaarr2-C253S
• Gene: Arrb2 Location: Chr11:70323461-70331654 bp, + strand Genetic Position: Chr11, 42.99 cM
• Alliance: Arrb2^tm1Stam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262395
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Single point mutation
• Mutation details: A G to C mutation was inserted creating a C253S substitution. Expression levels of the mutant protein in the heart are similar to wild-type expression levels. This mutation prevents S-nitrosylation at this site. (J:262395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arrb2 Mutation: 27 strains or lines available

References

• Original: J:262395 Hayashi H, et al., S-Nitrosylation of beta-Arrestins Biases Receptor Signaling and Confers Ligand Independence. Mol Cell. 2018 May 3;70(3):473-487.e6
• All: 1 reference(s)