Tex22tm1Osb
Targeted Allele Detail
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Symbol: |
Tex22tm1Osb |
Name: |
testis expressed gene 22; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University |
MGI ID: |
MGI:6194912 |
Synonyms: |
Tex22tm1a(EUCOMM)Osb |
Gene: |
Tex22 Location: Chr12:113038122-113052537 bp, + strand Genetic Position: Chr12, 61.57 cM, cytoband F2
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Alliance: |
Tex22tm1Osb page
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Allele Type: |
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Targeted (Conditional ready, Null/knockout, Reporter) |
Mutation: |
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Insertion
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Mutation details: The L1L2_Pgk_P cassette was inserted at position 113051633 of Chromosome 12 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 113052817. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:234235)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tex22 Mutation: |
18 strains or lines available
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Original: |
J:234235 Miyata H, et al., Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7704-10 |
All: |
1 reference(s) |
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