Pdgfc^tm3633Arte
Targeted Allele Detail

Summary

• Symbol: Pdgfc^tm3633Arte
• Name: platelet-derived growth factor, C polypeptide; targeted mutation 3633, TaconicArtemis
• MGI ID: MGI:6194942
• Synonyms: PDGF-CC^hum, Pdgfc^{tm3633(K242T, K246R, R299S, K318R, N342S, A343T)Arte}
• Gene: Pdgfc Location: Chr3:80943723-81121347 bp, + strand Genetic Position: Chr3, 35.73 cM
• Alliance: Pdgfc^tm3633Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263231
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: Based on NCBI transcript NM_019971_2, nucleotide substitutions were made that altered the following codons: K242T, K246R and R299S mutations have been introduced into exon 5, and K318R, N342S and A343T mutations have been introduced into exon 6. These mutations alter the mouse sequences to mimic the human amino acid sequence. (J:263231)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfc Mutation: 35 strains or lines available

References

• Original: J:263231 Zhang S, et al., Metabolic benefits of inhibition of p38alpha in white adipose tissue in obesity. PLoS Biol. 2018 May;16(5):e2004225
• All: 3 reference(s)