Alpk1^em1Fsha
Endonuclease-mediated Allele Detail

Summary

• Symbol: Alpk1^em1Fsha
• Name: alpha-kinase 1; endonuclease-mediated mutation 1, Feng Shao
• MGI ID: MGI:6196611
• Gene: Alpk1 Location: Chr3:127463959-127574176 bp, - strand Genetic Position: Chr3, 56.54 cM, cytoband H1
• Alliance: Alpk1^em1Fsha page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cas9 mRNA and gRNA (5'-GGCCCTTCGTGCCTGAAAAG-3') genome editing is used to introduce an 11 bp deletion in exon 3. (J:264436)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Alpk1 Mutation: 76 strains or lines available

References

• Original: J:264436 Zhou P, et al., Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose. Nature. 2018 Aug 15
• All: 1 reference(s)