Saa3^em1Capi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Saa3^em1Capi
• Name: serum amyloid A 3; endonuclease-mediated mutation 1, Carol Pilbeam
• MGI ID: MGI:6199070
• Gene: Saa3 Location: Chr7:46361422-46365100 bp, - strand Genetic Position: Chr7, 30.51 cM
• Alliance: Saa3^em1Capi page

Mutation origin

• Strain of Origin: CD-1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Undefined
• Mutation details: Two in-frame nonsense mutations (TAA and TGA) were introduced into exon 1 using an sgRNA and a template oligonucleotide with CRSIPR/Cas9 technology. This mutation creates a p.L14X (p.Leu14Stop) mutation resulting in a severely truncated open reading frame. (J:264824)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Saa3 Mutation: 18 strains or lines available

References

• Original: J:264824 Choudhary S, et al., Continuous PTH in Male Mice Causes Bone Loss Because It Induces Serum Amyloid A. Endocrinology. 2018 Jul 1;159(7):2759-2776
• All: 1 reference(s)