Tg(Ntrk2-cre/ERT2)#Phep
Transgene Detail

Summary

• Symbol: Tg(Ntrk2-cre/ERT2)#Phep
• Name: transgene insertion, Paul A Heppenstall
• MGI ID: MGI:6201344
• Synonyms: TrkB^CreERT2
• Transgene: Tg(Ntrk2-cre/ERT2)#Phep Location: unknown
• Alliance: Tg(Ntrk2-cre/ERT2)#Phep page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Ntrk2-cre/ERT2)#Phep expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ntrk2 (MGI:97384)

• Mutation details: A cassette containing a modified CreERT2-pA-Frt-Ampicillin-Frt was inserted in the first coding ATG of exon 2 into a bacterial artificial chromosome (BAC) containing the Ntrk2 mouse locus (RP23-391J8) deleting the entire coding region of exon 2. Purified BAC cDNA was purified and injected into pronuclei of B6D2F1/N oocytes or prepared for intracytoplasmic sperm injection (ICSI). Both methods produced transgenic offspring. Line numbers were not indicated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:265202)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ntrk2 (mouse) Summary of all recombinase alleles driven by Ntrk2. Alliance mouse Ntrk2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:265202 Dhandapani R, et al., Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons. Nat Commun. 2018 Apr 24;9(1):1640
• All: 1 reference(s)