Hrh1^em1Rei
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hrh1^em1Rei
• Name: histamine receptor H1; endonuclease-mediated mutation 1, Marc L Reitman
• MGI ID: MGI:6231184
• Gene: Hrh1 Location: Chr6:114374897-114459432 bp, + strand Genetic Position: Chr6, 53.05 cM
• Alliance: Hrh1^em1Rei page

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Endonuclease-mediated recombination created a 1,052 bp deletion leaving only the first 433 bp intact. (J:266037)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hrh1 Mutation: 35 strains or lines available

References

• Original: J:266037 Jain S, et al., Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E357-E366
• All: 1 reference(s)