Icos^{tm1.1(Hbegf)Anjm}
Targeted Allele Detail

Summary

• Symbol: Icos^{tm1.1(Hbegf)Anjm}
• Name: inducible T cell co-stimulator; targeted mutation 1.1, Andrew N J McKenzie
• MGI ID: MGI:6256735
• Synonyms: iCOS-DTR
• Gene: Icos Location: Chr1:61017086-61039479 bp, + strand Genetic Position: Chr1, 30.6 cM
• Alliance: Icos^{tm1.1(Hbegf)Anjm} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263583
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Icos^{tm1.1(Hbegf)Anjm} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hbegf

• Mutation details: A floxed cassette containing an ATG start site, IRES2 sequence, DTR (Hbegf; source species unknown) gene, and FRT-flanked neomycin resistance cassette was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. (J:263583)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Icos Mutation: 35 strains or lines available

References

• Original: J:263583 Oliphant CJ, et al., MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion. Immunity. 2014 Aug 21;41(2):283-95
• All: 3 reference(s)