Spry1^tm1.1Ssan
Targeted Allele Detail

Summary

• Symbol: Spry1^tm1.1Ssan
• Name: sprouty RTK signaling antagonist 1; targeted mutation 1.1, Shomyseh Sanjabi
• MGI ID: MGI:6270390
• Synonyms: Spry1^flx
• Gene: Spry1 Location: Chr3:37694096-37698747 bp, + strand Genetic Position: Chr3, 18.46 cM
• Alliance: Spry1^tm1.1Ssan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 3 was flanked by a loxP site on one side and a loxP site flanked neomycin resistance gene cassette on the other. The neo cassette was deleted by transiently transfection of an expression vector of Cre recombinase in the ES cells. (J:265930)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spry1 Mutation: 15 strains or lines available

Notes

The version of this allele that contains the neomycin selection cassette, Spr1^tm1Ssan, has been analyzed.

References

• Original: J:265930 Shehata HM, et al., Lack of Sprouty 1 and 2 enhances survival of effector CD8(+) T cells and yields more protective memory cells. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8939-E8947
• All: 2 reference(s)