Ppara^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Ppara^tm1.1Ics
• Name: peroxisome proliferator activated receptor alpha; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:6273327
• Synonyms: Pparalpha^flox
• Gene: Ppara Location: Chr15:85619184-85687020 bp, + strand Genetic Position: Chr15, 40.42 cM
• Alliance: Ppara^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268779
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance cassette was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exon 4 floxed. (J:268779)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppara Mutation: 44 strains or lines available

References

• Original: J:268779 Montagner A, et al., Liver PPARalpha is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. Gut. 2016 Jul;65(7):1202-14
• All: 10 reference(s)