Tnfrsf1b^{tm1.1(Tnfrsf1b)Sned}
Targeted Allele Detail

Summary

• Symbol: Tnfrsf1b^{tm1.1(Tnfrsf1b)Sned}
• Name: tumor necrosis factor receptor superfamily, member 1b; targeted mutation 1.1, Sergei A Nedospasov
• MGI ID: MGI:6279273
• Synonyms: hTNFR2KI
• Gene: Tnfrsf1b Location: Chr4:144940033-144973440 bp, - strand Genetic Position: Chr4, 78.17 cM
• Alliance: Tnfrsf1b^{tm1.1(Tnfrsf1b)Sned} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268706
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed human sequence spanning exon 2 through intron 6 with an FRT-flanked neomycin resistance cassette within the human intron 6 replaced the mouse sequence. Flp-mediated recombination removed the selection cassette. (J:268706)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf1b Mutation: 41 strains or lines available

References

• Original: J:268706 Atretkhany KN, et al., Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13051-13056
• All: 1 reference(s)