Grin2btm2.1Nhk
Targeted Allele Detail
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Symbol: |
Grin2btm2.1Nhk |
Name: |
glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 2.1, Noboru H Komiyama |
MGI ID: |
MGI:6280324 |
Synonyms: |
GluN2BdeltaCaMKII |
Gene: |
Grin2b Location: Chr6:135690231-136150509 bp, - strand Genetic Position: Chr6, 66.38 cM
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Alliance: |
Grin2btm2.1Nhk page
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Germline Transmission: |
Earliest citation of germline transmission:
J:271055
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Not Applicable) |
Mutation: |
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Nucleotide substitutions
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Mutation details: Three mutations, a leucine to alanine at amino acid 1298, an arginine to asparagine at amino acid 1300, and a serine to aspartate at amino acid 1303 (L1298A/R1300N/S1303D), were introduced in the CTD2B sub-region, and a loxP-flanked neomycin phosphotransferase gene driven by a compound phosphoglycerate kinase (PGK) and EM7 promoter was inserted. The mutations abrogate CaMKII binding to Grin2b. Cre-mediated recombination removed the neo cassette.
(J:271055)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Grin2b Mutation: |
97 strains or lines available
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Original: |
J:271055 McKay S, et al., The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences. Cell Rep. 2018 Oct 23;25(4):841-851.e4 |
All: |
1 reference(s) |
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