Mto1^tm1Tomik
Targeted Allele Detail

Summary

• Symbol: Mto1^tm1Tomik
• Name: mitochondrial tRNA translation optimization 1; targeted mutation 1, Kazuhito Tomizawa
• MGI ID: MGI:6281142
• Gene: Mto1 Location: Chr9:78355372-78381447 bp, + strand Genetic Position: Chr9, 43.65 cM, cytoband E1
• Alliance: Mto1^tm1Tomik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271287
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 1-2 were replaced with a neomycin-resistance gene. (J:271287)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mto1 Mutation: 37 strains or lines available

References

• Original: J:271287 Fakruddin M, et al., Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease. Cell Rep. 2018 Jan 9;22(2):482-496
• All: 1 reference(s)