Pi4ka^tm1.1Tbal
Targeted Allele Detail

Summary

• Symbol: Pi4ka^tm1.1Tbal
• Name: phosphatidylinositol 4-kinase alpha; targeted mutation 1.1, Tamas Balla
• MGI ID: MGI:6294260
• Synonyms: PI4KA^fl
• Gene: Pi4ka Location: Chr16:17098215-17224178 bp, - strand Genetic Position: Chr16, 10.71 cM
• Alliance: Pi4ka^tm1.1Tbal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273563
• Parent Cell Line: BAC-BA1 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S/SvEv)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT- and loxP-flanked neomycin selection cassette was inserted upstream of exon 48 and a loxP site was inserted downstream of exon 48. Flp-mediated recombination removed the selection cassette and left exon 48 floxed. (J:273563)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pi4ka Mutation: 126 strains or lines available

References

• Original: J:273563 Bojjireddy N, et al., Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. J Biol Chem. 2014 Feb 28;289(9):6120-32
• All: 2 reference(s)